多巴胺系统的体温调节作用

　　摘　要：多巴胺是当前研究得最有成效的脑内神经递质，且与其它脑内神经递质系统有着密不可分的联系。近年来研究发现，多巴胺及其受体对于体温调节具有重要意义，而且两类亚型的多巴胺受体参与体温调节的作用和机理可能不同，本文就多巴胺和各种多巴胺亚型受体研究现状，尤其是参与体温调节过程中的研究进展，作一综述报告。

　　参考文献：

　　［1］姚志彬，陈以慈主编．脑研究前沿、广东科技出版社，1995，300～18

　　［2］Seeman P, Van Tol H. Dopamine receptor pharmacology.Trends Pharmacol Sci, 1994, 15(7):264

　　［3］Sibley DR, Monsma FJ. Molecular biology of dopamine receptors. Trends Pharmacol sci, 1992, 13(2): 61

　　［4］韩济生主编．神经科学纲要．北京医科大学-中国协和医科大学联合出版社，1993，365～82

　　［5］韩济生，关新民．医用神经生物学．武汉出版社，1996，71～98

　　［6］Faun JE, Crocker AD. The effect of selective dopamine receptor agonists and antagonist on body temperature in rats. Eur J pharmacol, 1987, 133:243

　　［7］Salmi P, Jimenez P, Ahlenius S. Evidence for specific involvement of dopamine D1 and D2 receptors in the regulation of body temperature in the rat. Eur J phamacol, 1993, 236(3/4) :395

　　［8］Miilan M J, Peglion JL, Vian J, et al. Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic Da receptor mediates hypothermia, whereas blockade of D2 receptor elicits prolactin secretion and catalepsy.J Pharmacol Exp ther, 1995, 275(2): 885

　　［9］Faun JE, Crocker AD. The effect of selective dopamine receptor agonlsts and antagonist on body temperature in rats. Eur J pharmacol, 1987, 133: 243

　　［10］Verman A, Kulkarni SK. Differential role of dopamine receptor subtypes in thermoregulation and stereotypic behavior in naive and reserpinized rats. Arch Int pharmacodyn, 1993, 324:17

　　［11］Costentin J, Duterte-Boucher D, Panissaud C, et al. Dopamine D1 and D2 receptors mediate opposite effects of apomorphine on the body temperature of reserpinizad mice. neuropharmacology, 1990, 29(1): 31

　　［12］Subrsmaniam S, Lucki I,McGonjgle P. Effects of chronic treatment with selective agonista on the subtypes of dopamine receptors. Brain res, 1992, 571(2): 313

　　［13］Srivastava AK, Srivastava YP, Cupta PP, et al. Characterization of dopamine receptors involved in central thermoregulation in rabbits. Indian J Exp biol, 1991, 29(9): 1087

　　［14］Vasse M, Chagrsoui A, Hemy JP, et al. The rise of body temperature induced by the stimulation of dopamine D1 receptor is increased in acutely reserpinized mice. Eur J pharmacol, 1990,181(1): 23

　　［15］Meller E, Hizami R, Kreuter L. Hypothermia in mice: D2 dopamine receptor mediation and absence of spare receptors.Pharmacology Biochem behavior, 1989, 32(1): 141

　　［16］Parada MA, M de paracla M P, Rads P, et al. Sulpiride increases and dopamine decreases intracrsnial temperature in rats when injected in the lateral hypothalamus: an animal model for the neumleptic malignant syndrome? Brain res, 1995,674 (1):117

　　［17］Verman A, Kulkarni SK. Dopamine receptor mediated hypothermic action of B-HT 920 in rats. J Pharm pharmacoi, 1991,43(6): 421

　　［18］Double KL, Crocker AD. Effects of inactivation of Di dopamine receptors on stereotypic and thermic responses to quinpirole (LY171555). Neuroeci lett, 1990, 115(1): 81

　　［19］Boyar we, Altar CA, Modulation of in vivo dopemine resease by D2 but not D1 receptor agonista and antagonists. J neurochem, 1987, 48(3):824

　　［20］Aretha CW, Galloway MP. Dopamine autoreceptor reserve in vitro: possible role of dopamine D3 receptors. Eur J Pharmacol,1996, 305(1-3): 119

　　［21］Gainetdinov RR, Sotnikova TD, Grekhova TV, et al. In vivo evidence for preferential role of dopamine Da receptor in the presynaptic regulation of dopamlne release but not synthesis.Eur J pharmacol, 1996, 308(3): 261

　　［22］Yamawaki S, Lai H, Horita A. Dopaminergic and serotonargic mechanisms of thermoregulation: mediation of thermal elfects of apomorphine and dopamina. J Pharmacoi Exp Ther,1983, 227(2): 383

　　［23］Suaudeau C, Dourmap N, Costentin J. Rapid and long lasting reduction of the hypothermic effect of a D2 dopamine agonist after an intracerebroventricular injection of 6-hydroxydopamine.Neuropharmacology, 1995, 34(1): 101