12 Haberkorn U, Khazaie K, Morr I, Altmann A, Muller M, VanKaick G. Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase. Nucl Med Biol, 1998;25:367-373
13 Balzarini J, Degreve B, Andrei G, Neyts J, Sandvold M, Myhren F, de Clercq E. Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged introcellular retention of ganciclovior anabolites in herpes simplex virus type 1 thymidine kinase gene transfected liver cells. Gene Ther, 1998;5:419-426
14 Tong XW, Engehausen DG, Kaufman RH, Agoulnik I, Contant C, Freund CT, Oehler MK. Improvement of gene therapy for ovarian cancer by using acyclovir instead of ganciclovir in adenovirus mediated thymidine kinase gene therapy. Anticancer Res, 1998;18(2A):713-718
15 Grignet-Debrus C, Calberg-Bacq CM. Potential of vericella zoster virus thymidine kinase as a suicide gene in breast cancer cells. Gene Ther, 1997;4:560-569
16 Degreve B, Andrei G, Izquierdo M, Piette J, Morin K, Knaus EE, Wiebe LI. Vericella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer. Gene Ther, 1997;4:1107-1114
17 Rowley S, Lindauer M, Gebert JF, Haberkorn U, Oberdorfer F, Moebius U, Herfarth C. Cytosine deaminase gene as a potential tool for the genetic therapy of colorectal cancer. J Surg Oncol, 1996;61:42-48
18 Hoganson DK, Batra RK, Olsen JC, Boucher RC. Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma. Cancer Res, 1996;56:1315-1323
19 Dong Y, Wen P, Manome Y, Parr M, Hirshowitz A, Chen L, Hirschowitz EA. In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Hum Gene Ther, 1996;7:713-720
20 Rainov NG, Dobberstein K-U, Sena-Esteves M, Herrlinger U, Kramm CM, Philpot RM, Hilton J. New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol. Hum Gene Ther, 1998;9:1261-1273
21 Manome Y, Wen PY, Dong Y, Tanaka T, Mitchell BS, Kufe DW, Fine HA. Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Nat Med, 1996;2:567-573
22 Tamiya T, Ono Y, Wei MX, Mroz PJ, Moolten FL, Chiocca EA. Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine. Cancer Gene Ther, 1996;3:155-162
23 Ono Y, Ikeda K, Wei MX. Regression of experimental brain tumors with 6 -thioxanthine and Escherichia coli gpt gene therapy. Hum Gene Ther, 1997;8:2043-2055
24 Green NK, Young DJ, Neoptolemos JP, Friedlos F, Knox RJ, Springer CJ, Anlezark GM. Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2, 4-dinitrobenzamide(CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene. Cancer Gene Ther, 1997;4:229-238
25 Bridgewater JA, Knox RJ, Pitts JD, Collins MK, Springer CJ. The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cellpermeable metabolite. Hum Gene Ther, 1997;8:709-717
26 Marais R, Spooner RA, Stribbling SM, Light Y, Martin J, Springer CJ. A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy. Nat Biotechnol, 1997;15:1373-1377
27 Danks MK, Morton CL, Pawlik CA, Potter PM. Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11. Cancer Res, 1998;58:20-22
28 Aghi M, Kramm CM, Chou TC, Breakefield XO, Chiocca EA. Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. J Natl Cancer Inst, 1998;90:370-380
29 Uckert W, Kammertons T, Haack K, Qin Z, Gebert J, Schendel DJ, Blankenstein T. Double suicide gene(cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumors cell in vivo. Hum Gene Ther, 1998;9:855-866
30 Ishii-Morita H, Agbaria R, Mullen CA, Hirano H, Koeplin DA, Ram Z, Oldfield EH. Mechanism of “bystander effect" killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment. Gene Ther, 1997;4:244-255
31 Yang L, Chiang Y, Lenz HJ, Danenberg KD, Spears CP, Gordon EM, Anderson WF. Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ganciclovir based gene therapy of human gastrointestinal tumor cells. Hum Gene Ther, 1998;9:719-728
32 Park JY, Elshami AA, Amin K, Rizk N, Kaiser LR, Alberda SM. Retinoids augment the bystander effect in vitro an
