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当前位置:健康网>>基础医学>>解剖学>> 酪氨酸蛋白激酶抑制剂的研究进展

酪氨酸蛋白激酶抑制剂的研究进展


发布:www.liulingling.com 来源:医学杂志

  摘 要:酪氨酸蛋白激酶(PTK)广泛存在于细胞的各种生理过程中,是主要与细胞的生长增殖和分化有关的信号途径。因此,PTK抑制剂具有广泛的多样的生物效应,本文回顾了近年来对PTK抑制剂的研究进展:新型PTK抑制剂的结构活性关系;PTK抑制剂对肿瘤细胞和正常细胞的影响。参考文献:

  [1]Jin Najia, Rafat A, Denis E, et al. Communication between tyrosine kinase pathway and myosin light chain kinase pathway in smooth muscle. American Physiology, 1996, 271(4 part 2): H1348

  [2]柴希运,秦慧,陈惠黎.蛋白激酶与细胞分化——两种分化诱导剂对酪氨酸蛋白激酶的抑制.生物化学杂志,1993,9: 162

  [3]Sharpe T R, Vasios G W. PTK inhibitors for treating osteoarthritis. PCT Int Appl WO 97, 1997, Apr: 11692,3

  [4]Traxler P M, Marc L. PTK inhibitors in cancer treatment. Expert Opin Ther Pat, 1997, 7(6): 571

  [5]Trazler P M, Furet P, Marc L, et al. Design and synthesis of novel tyrosine kinase inhibitors using a pharmacophore model of ATP-binding site of the eGFR. J Pharm Belg, 1997, 52(2): 88

  [6]Traxler P M, Bold G, Frei J, et al. Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: 4(phenylamino) pyrazolo-[3,4-d] pyrimidines. J Med Chem, 1997, 40(22): 3601

  [7]Gordon W, Alexander J B, David W F, et al. PTK inhibitors 12 synthesis and structure-activity relationships for 6-substituted 4-(phenylamino) pyrimido [5,4-d] pyrimidines designed as inhibitor of the eGFR. J Med Chem, 1997, 40(12): 1820

  [8]Thompson A M, Alexander J B, David W F, et al. Tyrosine kinase inhibitor 7,7-amino-4(phenylamino)-and 7-amino-4-[(phenylmethyl)amino] pyrido [4,3-d]-primidines; a new class of inhibitor of the tyrosine kinase activity of the eGPR. J Med Chem, 1995, 38(19): 3780-8

  [9]Zhu Jiangyum, Shore S K c-ABLtyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein. Mol Cell biol, 1996, 16(12): 7054

  [10]Nishi T, Budde R J A, John S, et al. Tight-binding inhibitory sequences against pp60c-Src identified using a random 15-amino acid peptide. FEBS lett, 1996, 399(3): 237

  [11]Garcia-Echeverria C. Acylated oligopeptides containing phosphotyrosine as inhibitors of protein tyrosine kinase. PCT Int Appl, 1997, Feb, 27: 07131

  [12]Garia-Echeverria C, Gay B. Acylated oligopeptide derivatives having cell signal inhibitory activity. PCT Int Appl 1997, Mar, 6: 08193

  [13]Battisjini C, Ballinari T. Substituted indolymethylene-oxindol analogs as tyrosine kinase inhibitors. PCT Iht Appl WO, 96: 32380

  [14]Showalter H D H, Sereel A D, Boguslawa M L, et al. Tyrosine kinase inhibitors 6 structure-activity relationship among Nand 3-substituted2,2′-diselenobis (1H-indoles) for inhibition of protein tyrosine kinase and comparative in vitro and in vivo studies against selected sulfur congeners. J Med chem, 1997, 40(4): 413

  [15]Burns C J, Howell C. Effect of PTK inhibitors on β-cell proliferation. Biochem Soc trand, 1997, 25(1): 177S

  [16]Imoto M, Simizu S, Doki Y, et al. Induction of apoptotic cell death by PTK inhibitor. Nippon Nogei Kayaku kaishi, 1997, 71(5): 523

  [17]Iwagoe H, Hivotsugu K, Kazuhiko F, et al. Inhibitory effect of tyrosine kinase inhibitors in antigen-induced tracheal contraction and histamine release in guinea pigs. International Achires of Allergy and Immunology, 1996, 111(3): 291

  [18]Masumoto N, Nakayama K. Specific attenuation of the pressure-induced contraction of rat cerebral artery by herbmycin A. Eur J pharmacol, 1997, 330(1): 55

  [19]Grignon S, Nicolas L, Francois C, et al. Tyrosine kinase inhibitors and cycloheximide inhibit Li+ protection of cerebella granular neurons switched to nondepolarizing medium. Eur J Pharrfiacol 1996, 315(1): 111

  [20]Nakagohri T, Asano T. Effects of tyrosine kinase inhibitor on liver ischemic reperfusion injuries. Ther Res 1996, 17(11) 4206

  [21]Ma H, Hiroshi M, Bing L, et al. Regulation of PDGF-βreceptor-operated Ca+ channels by phospholipase c-ri in glomerular mesangial cells. Amer Physiol, 1996, 271 (5 part 2): F994

  [22]Wu Jiying, Cohen I S. Tyrosine kinase inhibition reduces if in rabbit ainoatrial node myocytes. Pfiuegers Arch 1997, 434(5): 509

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  [24]Kralisz U, Cierncewahi C S. Different effect of the tyrosine kinase inhibitors on collagen type 1-induced platelet aggregation and adhesion to this protein. Thromb res, 1997, 86(4): 287

  [25]Yura Y, Kusaka J, Taujimoto H, et al. Effect of protein tyrosine kinase inhibitors on the replication of herps simplex virus and the phosphorylation of viral proteins. intervirology, 1997, 40(1): 7

  [26]Klein B Y, Tepper S H. Opposing effect of tyrosine kinase inhibitors on mineralization of normal and tumor bone ceils. J Cell biochem, 1997, 65(3): 420


 

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