28.Brooks PC,Clark RAF,Cheresh DA.Requirement of vascular int egrin αvβ3 for angiogenesis.Science,1994,264:569
29.Drake CJ,Cheresh DA,Little CD.An antagonist of integrin α v β3 prevents maturation of blood vessels during embryonic neovascularization. J Cell Sci，1995,108:265s
30.Brooks PC,Stromblad S,Sanders LC,et al.Localization of matri x metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3 Cell,1996,85：683
31.Stefansson S,Lawrence DA.The serpin PAI-1 Inhibits cell mig ration by blocking integrin αvβ3 binding to vitronectin.Nature,1996,383:4 41
32.Carmeliet P,Mackmano N,Moons L,et al.Role of tissue factor i n embryonic blood vessel development.Nature,1996,383:73
33.Cui J O,shea KS,Purkayastha A,et al.Fetal haemorrhage and in complete block to embryogenesis in mice lacking coagulation factor V.Nature,1996 ,384:66
34.McClain SA,Simon M,Jones E,et al.Mesenchymal cell activatio n is the rate-limiting step of granulation tissue induction.Am J Pathol 1996,14 9,(4):1257
35.Witke W,Sharpe AH,Hartwig JH,et al.Hamostatic,inflammatory a nd fibroblast responses are blunted in mice lacking gelsolin.Cell,1995,81:41
36.Darnell J,Lodish H,Baltimore D,et al.Molecular cell biology. 3rd.1995,Freeman WH and Company.NY,1862.
37. Desmouliere A.Apoptosis Mediates the decreases in celluarit y during the transition between granulation tissue and scar.Am J Pathol,1995,146 (1):56
38.Hubner G,Hu QJ,Smola H,et al.Strong induction of activin exp ression after injury suggests an important role of activin in wound repair.Dev B iol,1996,173:490
39.Longaker MT,Whitby DJ,Ferguson MWJ,et al.Adult skin wounds i n the fetal environment healing with scar formation.Ann Surg,1994,219：65
40.Morykwas MJ,Ditesheim JA,Ledbetter MS,et al.Monodelphis dome sticus:A model for early developmental wound healing.Ann Plast Surg,1991,27:327
41.Lorenz HP,Longaker MT,Perkcha LA,et al.Scarless wound repair :a human fetal skin model.Developnment,1992,114:253
42.Shah M,Foreman DM.Ferguson MWJ growth factor.Lancet,1992,339 :213
43.Shah M,Foreman DM,Ferguson MWJ.Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduc es scarring.J Cell Sci,1995,108:985
44.Border WA,Noble NA.Transforming growth factor β in tiss ue fibrosis.N Engl J Med,1994,331:1286
45.Abergel RP,Pizzurro D,Meeker CA,et al.Biochemical compositio n of the connective tissue in keroids and analysis of collagen metabolism in kel oid fibroblast cultures.J Invest Dermatol,1985,84:384
46.Longaker MT,Whitby DJ,Adzick NS,et al.Studies in fetal wound s healing:VI.Second and early third trimester fetal wounds demonstrate rapid col lagen deposition without scar formation,J Podiatr Surg,1990,25:63
47.DDi Cessare PE,Cheung DT,Perelman N,et al.Alteration of coll agen composition and cross linking in keloid tisssue.Matrix,1990,10:172
48.Hardingham TE,Fosang AJ.Proteoglycans:Many forms and many fu nction.FASEB,1992,6:861
49.Adzick NS,Lorenz HP.Cells,matrix,growth factors and the surg eon.Ann Surg,1994,220:10
