创伤愈合的细胞生物学研究进展 3

来源:医学杂志 2007-01-14 03:24:38 

成人不同的原因至今还是个谜,也许在了解其中真正原因 之际也正是彻底解决疤痕增生问题之时。

  创伤愈合的研究已取得了很大进展,特别是近几年来,随着细胞和分子生物学研究手段和 方法的不断改进和完善,创伤愈合的研究也已从单纯对伤后形态学,生化变化的研究发展到 对引起变化的机制研究。相信今后的几年创伤愈合的研究将更加激动人心并更加深人们对细 胞和分子生物学的理解。

参 考 文 献

  1.Mayadas TN,Johnson RC,Rayburn H,et al.Leukocyte rolling and extravas ation are severely compromised in P selectin-deficient mice.Cell,1993,74:541

  2.Springer TA.Traffic signals for lymphocyte recirculation and leukocy te emigration:the multistep paradigm.Cell,1994,76:301

  3.Belligan GJ,Caldwell H,Howie SEM,et al.In vivo fate of the in flammatory macrophage during the resolution of inflammation.J Immunol,1996,157:2 577

  4.Saarialho-Kere UK,Pentland AP,Birkedal-Hansen H,et al.Disti nct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds.J Clin Invest,1994,94(1):79

  5.Romer J,Lund LR,Eriksen,et al.The receptor for urokinase-typ e plas minogen activator is expression by keratinocytes at the leading edge during reep ithelialization of mouse skin wounds.J Invest Dermatol,1994,102(4):529

  6.Pawar S,Kartha S,Toback FG.Differential gene expression in m igrating renal epithelial cells after wounding.J Cell Physiol,1995,165:556

  7.Sun TT,Costarolis G,Lavker RM.Hair follicle stem cell:the bul ge-activation hypothesis.J Invest Dermal,1991,96:77s

  8.Mitchson TJ,Cramer LP.Actin-Based cell motility and cell loc omotion.Cell,1996,84:371

  9.De Luca M,pellegrini G,Zambruno G,et al.Role of integrin in c ell adhesion and polarity in normal kerationcytes and human skin pathologies.J D ermatol,1994,21(11):821

  10.Garlick JA,Taichman LB.Fate of human keratinocytes during re epithelialization in an organotypic culture model.Lab Invest,1994,70(6):916

  11.Nobes CD,Hall A.Rho,Rac and cdc 42 GTP ase regulate the asse mbly of multimolecular focal complexes associated with actin sress fibers,lamell ipodia and filopodia.Cell,1995,81:53

  12.Cheu JD,Kim JP,Zhang K,et al.Epidermal growth factor (EGF) p romotes Hunan keratinocyte locomotion on collagen by incressing the alpha2 i ntegrin subunit.Exp Cell Res,1993,209(2):216

  13.Madlener,Mauch C,Conca W,et al.Regulation of the expression of stromelysin-2 by growth factor in keratinocytes:implications for normal and impaired wound healing.Biochem J,1996,320:659

  14.Mikami H,Watanabe S,Hirose M,et al.Role of extracellular mat rix in wound repair by cultured gastric mucosal cells.Biochem Biophys Res Commun ,1994,202:285

  15.Grzesiak JJ,Pierschbacher MD.Shifts in the concentrations of magnesium and calcium in early porcine and rat wound fluids activate the cell m igratory response.J Clin Invest,1995,95(1):227

  16.Compton CC,Gill JM,Bradford DA,et al.Skin regenerated from c ultured epithelial autografts on Full-thickness burn wound from 6 day to 5 year s after grafting-a light,electron microscopic and immunohistochemical study.Lab Invest,1989,60:600

  17.Ansprunk OH,Folkman J.Migration and proliferation of endothe lial cell in perfomed and newly formed blood vessels during tumor angiogenesis.M icrovas Res,1977,14:53

  18.Sholley MM,Gimbrone MA Jr,Cotran RS.The effects of leukocyte depletion on corneal neovascularization.Lab Invest,1978,38:32

  19.Werner Risau.Mechanisms of angiogenesis.Nature,1997,386,17: 671

  20.Jakeman LB,Winer J,Bennett GL,et al.Binding sites for vascul ar endothelial growth factor are localized on endothelial cells in adult rat tis sue.J Clin Invest,1992,89:244

  21.Brown LF,Yeo KT,Berse B,et al.Expression of vascular permeab ility factor (Vascular Endothelial Growth Factor) by epidermal kerationcytes dur ing wound healing.J Exp Med,1992,176:1375

  22.Pepper MS,Ferrara N,Orci L,et al.Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibito r-1 in microvascular endothelial cells.Biochem Biophys Res Commun,1991,181:902

  23.Unemori EN,Ferrara N,Bauer EA,et al.Vascular endothelial gro wth fator induces interstitial collagenase expression in human endothelial cell s.J Cell Physiol,1992,153:557

  24.Zigzag D.Angiogenic growth factors in normal embryogensis an d neoplasia.Am J Pathol,1995,146(2):293

  25.Sato N,Beitz JG,Kato J,et al.Platelet-derived growth factor indirectly stimulates angiogenesis in vitro.Am J Pathol,1993,142:1119

  26.Broadley KN,Apuino AM,Woodward SC.Brief communication monosp ecific antibodies implicate basic fibroblasts growth factor in normal wound repa ir.Lab Invest,1989,61:571

  27.Clark RAF,Tonnesen MG,Gailit,et al.Transient functional expr ession of αvβ3 on vascular cells during wound repair.Am

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