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摘 要:神经营养因子对于维持交感神经和感觉神经系统的生长和发育极为重要,可预防甚至逆转基底前脑胆碱能神经元变性,使学习和记忆的功能得到恢复。近年来研究其在神经元变性的机制及诊断、治疗方面有重要价值。参考文献: [1]Serrano-Sanchez T,Diaz-Armesto I. Brain-derived growth factor :current aspects. Rev neurol, 1998,26(154): 1027 [2]Brooks AI,Halterman MW,Federoff HJ. Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization. neuroreport, 1999,10(2): 337 [3]Mahoney MJ,Saltzman WM. Millimeter-scale positioning of a nerve-growth factor source and biological activity in the brain.Proc Natl Acad Sci USA,1999,96(8):4536 [4]Gustilo MC,Markowska AL,Breckler SJ, et al. Evidence that nerve growth factor influences recent memory through structural changes in septohippocampal cholinergic neurons. J Comp neurol, 1999,405 (4): 491 [5]Hohn A,Leibrock J,Bailey K,et al. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature, 1990,344 (22): 339 [6]Pan W,Banks WA,Kastin AJ. Permeability of the blood-brain barrier to neurotrophins. Brain Res, 1998,788 (1-2): 87 [7]Schober A,Hertel R,Arumae U,et al. Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo. Neurosci,1999,19(6) :2008 [8]Haase G,Pettmann B, Bordet T,et al. Therapeutic benefit of ciliary neurotrophic factor in progressive motor neuronopathy depends on the route of delivery. Ann Neurol,1999,45(3):296 [9]Hogue-Angeletti R, Bradshaw RA. nerve growth factor from mouse submaxillary glands:amino acid sequence. Proc Natl Acad Sci USA,1971,68:2417 [10]Scott J,Selby M,Urdea M,et al. Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. Nature,1983,302(5908):538-40 [11]Guo LY,Zhu JF,Wu XF,et al. Cloning of a cDNA encoding a nerve growth factor precursor from the Agkistrodon halys Pallas. Toxicon,1999,37(3) :465 [12]Ha DH,Robertson RT,Ribak CE,et al. Cultured basal forebrain cholinergic neurons in contact with cortical cells display synapses, enhanced morphological features, and decreased dependence on nerve growth factor. J Comp neurol, 1996, 373(3):451 [13]Van Ooyen A, Willshaw DJ. Competition for neurotrophic factor in the development of nerve connections. Proc R Soc Lond B Biol Sci,1999,266(1422): 883 [14]Martinez-Scrrano A,Bjorklund A. Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middleaged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging. Proc Natl Acad Sci USA,1998,95(4) :1858 [15]Peterson GM, Ginn SR, Lanford GW. Fibers immunoreactive for nerve growth factor receptor in adult rat cortex and hippocampus minic the innervation pattern of aChE-positive fibers. Brain Res Bull,1994,33(2) :129 [16]Martinez-Scrrano A,Fischer W,Soderstrom S,et al. Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain. Proc Natl Acad Sci USA, 1996,93(13):6355 [17]Tuszynski MH,Roberts J,Senut MC, et al. Gene therapy in the adult primate brain:intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene ther, 1996,3 (4): 305 [18]Tuszynski MH, Smith DE, Roberts J, et al. Targeted intraparenchymal delivery of human NGF by gene transfer to the primate basal forebrain for 3 months does not accelerate beta-amyloid plaque deposition. Exp Neurol,1998,154(2):573 |
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