东方神丹对去势大鼠附属性腺的作用

　　摘　要：中药东方神丹粉剂对5月龄睾丸切除(去势肾虚证模型)雄性Wistar大白鼠术后灌胃6周，结果表明去势鼠前列腺、精囊腺、包皮腺、提肛肌出现明显萎缩，东方神丹、阳性对照药及丙酸睾丸素对前列腺、精囊腺及提肛肌具有明显抗萎缩作用，前列腺泡上皮细胞SDH酶活性增强。丙酸睾丸素作用最强，东方神丹优于阳性对照药，其器官重量指数明显增加，组问具有明显统计学差异。结果提示东方神丹具有丙酸睾丸素样作用，对维持附属性腺的发育和正常功能具有重要意义。

Effects of Chinese Traditional medicine-DFSD on Sexual Subsidiary Glands of Gelded Wistar Rats

cui Zhenguo,Deng Zhihua,Gui Li, et al(Liaoning Institute of Basic Medical Sciences, Shenyang 110005)

　　Abstract：Male Wistar rats of five months old were gelded, and a part of them were given Dong Fang Shen dan(DFSD) solution every day through mouth for six weeks. The rcsults were as fotlows : the prostates, seminal vesicles, Tyson’s glands and levator ani muscles of the gelded rats in the blank control group were obviously atrophic. The anti-atrophy effect of testosteron proionate was the strongest, and that of DFSD was weaker. The weight indexes of sexual subsidiary glands were significant greater than that of blank group. The activities of SDHase in the epithelia of prostates in the group treated with DFSD were stronger than that of the blank group. The above results shows that DFSD has testosteron-like effect, and it may maintain the development of sexual subsidiary glands and keep these organs exerting their normal functions when gelded.

　　Keywords：dong fangshen dan ; geld ; index of organ weight; SDHase ; rat参考文献：

　　［1］李连达．补肾壮阳药的主要药效学研究技术要求．中药新药与临床药理，1992，2(2)：4

　　［2］徐叔去．药理实验方法学，北京，人民卫生出版社，1991，1286～1415