通过本实验我们认为，血液中镁的浓度对偏头痛发作起着重要作用，并参与发病机制。其机制可能是因为体内外周血镁水平降低使脑内镁水平下降，一旦降至脑阈值水平(cerebral threshold level)，即可导致偏头痛发作［11］。我们通过镁盐(潘南金)治疗偏头痛取得较为满意的效果，推测血镁提高后使偏头痛发作阈值即脑阈值水平相应提高，为今后治疗偏头痛的发作找到一条新的途径。
参考文献
1 Ramadan NM, Halvorson H, Vande-Linde A, et al. Low brain magnesium in migraine. Headache, 1989, 29(7):416
2 Swanson DR. Migraine and magnesium, eleven neglected connections. Perspect Biol Med, 1988, 31(4):526
3 Anonymous. Headche Classification Committee of the Internation Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia, 1988,8(7):10
4 Goldstein S, Zsoter TT. The effect of magnesium on the response of smooth muscle to 5-hydroxytryptamine. Brit J Pharmacol, 1978, 62(5):507
5 Nowak L, Bregestovski P, Ascher P, et al. Magnesium gates glutamate-activated channels in mouse central neurons. Nature, 1984, 307(4):462
6 Foster AC, Fagg GE. Neurobiology. Taking apart NMDA receptor. Nature(London), 1987, 329(3):395
7 Altura BT, Altura BM. Withdrawal of magnesium causes vasospasm while elevated magnesium produces relaxation of tone in cerebral arteries. Neurosci Lett, 1980, 20(3):323
8 Altura BM and Altura BT. Magnesium electrolyte transport and coronary vascular tone. Drugs, 1984, 28(supply):109
9 邵美贞主编.镁的基础与临床.成都：四川科学技术出版社，1996.85
10 Alexander Mauskop, Bella T Altura, Roger Q, et al. Intravenous magnesium sulphate relieves migraine attraine attacks in patients with low serum ionized magnesium levels. Clinical Science, 1995, 89(7):633
11 Gallai V, Sarchielli P, Coata G, et al. Serum and salivary magnesium levels in migraine. Headache, 1992, 32(3):132
