4 IGFs对IUGR的诊断和治疗作用
孕晚期IUGR血浆中IGFBP-1水平与新生儿体质量呈负相关，但这时IUGR的临床表现也较明显，故对IGFBP-1检测只具有学术上的意义.Unterman等［17］对15～16wk孕妇羊水的IGFBP-1水平进行了测定，发现IGFBP-1对SGA诊断的敏感度为40%,特异度为84%.尽管单独检测IGFBP-1不足以作为诊断IUGR的方法，但如果联合其它的结合蛋白检测可能会有更好的结果.目前IGFs应用于IUGR的治疗还处于初步探索阶段，主要集中于动物器官促成熟的研究.临床上还未见报道.从实验学角度讲，母亲应用IGF-Ⅰ能够增强胎盘的功能，促进胎儿的生长，这给IUGR的宫内治疗提供了依据.
作者简介：张惠琴，女，35岁，主治医师，产科副主任.现为第四军医大学陕西省卫生厅研究生课程班学员.导师辛晓燕.电话：(029)8704650
作者单位：第四军医大学西京医院妇产科 陕西 西安 710033
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